The Manchester Police Departments Patrol Division is the largest in New Hampshire with 132 sworn officers. The Patrol Division is split into specialized units.

The largest unit in the division is Uniform.  Officers assigned to Uniform are responsible for providing twenty-four-hour, seven-day-a-week patrol and emergency coverage in the city. Aside from responding to emergency calls, officers assigned to Uniform patrol assigned areas take initial reports and enforce motor vehicle laws. Officers in Uniform currently cover three shifts with 112 officers and 21 supervisors divided between three shifts. Officers operate marked and unmarked vehicles while on patrol. Officers also patrol on mountain bikes, motorcycles, and on foot.

The city is divided into three sectors; each sector is split into patrol routes. The size of the patrol route is determined by the number of calls for service in the area. Officers are assigned to the same sector for extended periods of time, so they become familiar with the businesses and people living in the area. Each sector is supervised by a Sergeant.  Officers in Uniform also operate a prisoner transport wagon and the largest police department holding and booking facility in the state of New Hampshire, processing an average of fifteen prisoners a day.

The Manchester Police Department prides itself on having highly trained police officers. Before their Uniform assignment, officers receive almost one year of training, and this training continues once their assignment begins. New officers are encouraged to seek training that will help them develop their skills as patrol officers. Some of the training includes firearms skill building, high-risk patrol tactics, and evidence collection. As officers progress in their careers, many focus on training that will help them move to assignments in specialized divisions such as Community Policing or Investigations.